Altered GABAA,slow inhibition and network oscillations in mice
نویسندگان
چکیده
1 GABAA receptor β3 subunit 2 3 4 Harald Hentschke, Claudia Benkwitz, Matthew I. Banks, Mark G. Perkins, Gregg E. 5 Homanics and Robert A. Pearce 6 7 1. Department of Anesthesiology, University of Wisconsin, Madison, WI 53706, USA 8 2. Section of Experimental Anesthesiology, Department of Anesthesiology, Eberhard9 Karls-University, Tuebingen, Germany 10 3. Departments of Anesthesiology and Pharmacology, University of Pittsburgh School of 11 Medicine, Pittsburgh, Pennsylvania 15261, USA 12 13 14 Running head: Hippocampal inhibition via GABAAR β3 subunit 15 16 17 18 Address correspondence to: 19 Robert A. Pearce, M.D., Ph.D. 20 Department of Anesthesiology 21 University of Wisconsin 22 B6/319 Clinical Science Center 23 600 Highland Avenue 24 Madison, WI 53792 25 USA 26 Phone: (608) 263-0208 27 Fax: (608) 263-8111 28 E-mail: [email protected] 29 30 31 32 33 Articles in PresS. J Neurophysiol (October 21, 2009). doi:10.1152/jn.00651.2009
منابع مشابه
Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit.
Phasic GABAergic inhibition in hippocampus and neocortex falls into two kinetically distinct categories, GABA(A,fast) and GABA(A,slow). In hippocampal area CA1, GABA(A,fast) is generally believed to underlie gamma oscillations, whereas the contribution of GABA(A,slow) to hippocampal rhythms has been speculative. Hypothesizing that GABA(A) receptors containing the beta(3) subunit contribute to G...
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